The Division of Geriatric Medicine at NUH focuses its research efforts on extending the healthspan, preventing frailty and disability, and enhancing the quality of life for older adults. Our research encompasses a wide range, from prevention to end-of-life care, and from basic science to translational research and population health improvement. Our team is actively engaged in clinical research on value-based care and oncogeriatric and orthogeriatric subspecialties, with a strong emphasis on early access, holistic clinical management and the right siting of care. To achieve this, we work closely with basic scientists, clinical and community partners, maintaining a translational perspective to achieve tangible benefits for older adults. Our research focuses on two main areas:
1) Physical frailty
Physical frailty, characterised by weight loss, low grip strength, exhaustion, slow gait speed and low physical activity, is a common issue among older adults and a significant contributor to functional decline and early mortality. Our approach to addressing this geriatric syndrome is multi-pronged:
(A) Detection
We have developed an innovative web-based application for use in primary care and community settings to facilitate the timely identification of older adults living with pre-frailty1. This early detection allows for preventive and proactive care, enabling older adults to age in place without disability. This research project is a collaboration with the National University Polyclinic (NUP), Jurong Community Hospital (JCH), NUS's Saw Swee Hock School of Public Health (SSHSPH) and NUS Engineering.
(B) Exercise
Physical exercise and memory training have been found beneficial in preventing and delaying dementia and frailty. Our HAPPY (Healthy Aging Promotion Programme for you) community programme combines physical exercise (stretching, aerobic, resistance and balance), cognitive training and self-empowerment (www.straitstimes.com/singapore/programme-launched-to-help-frail-senior-citizens-maintain-mental-and-physical-health ). It is currently implemented in over 15 sites island-wide, in collaboration with community partners, and includes an ongoing volunteer training programme. During the COVID-19 pandemic, we successfully transitioned to an online platform to maintain the continuity of the programme. Participation in this programme has been shown to reduce the risk of depression and improve physical and cognitive function, as well as quality of life2.
Credit: todayonline
(C) Nutrition
Healthy ageing, as defined by the World Health Organisation in 2015, involves maintaining functional abilities for well-being in old age. Nutrition, particularly a high-protein diet, plays a crucial role in longevity and health span, stimulating muscle protein synthesis and helping delay the onset of frailty and/or sarcopenia. The Healthy Older People Everyday (HOPE) - Role of High Protein Diet in Reduction of Frailty and Sarcopenia project evaluates the acceptability and effectiveness of a high-protein diet in improving function and reducing disability among community-dwelling seniors. This research project is in collaboration with the Health Promotion Board (HPB) and SSHSPH.
2) Immunosenescence
Immunosenescence, the age-related decline in the immune system characterised by chronic inflammation throughout the body, increases the risk of infection and severity of infections in older adults and diminishes responses to vaccination. This area of study has become particularly crucial during the COVID-19 pandemic. We are conducting an in-depth basic science study examining the local older population's response to COVID-19 mRNA vaccination. The findings of this study will help us understand the mechanisms behind poorer vaccination responses in older adults and identify potential targets for intervention.
References
- Merchant et al. Rapid Geriatric Assessment Using Mobile App in Primary Care: Prevalence of Geriatric Syndromes and Review of Its Feasibility. Front Med (Lausanne). 2020 Jul 8;7:261.
- Merchant et al. Community-Based Peer-Led Intervention for Healthy Ageing and Evaluation of the "HAPPY" Program. J Nutr Health Aging. 2021;25(4):520-527.
Selected List of Publications
Publications
1. Merchant RA, Ho VWT, Chen MZ, Wong BLL, Lim Z, Chan YH, Ling N, Ng SE, Santosa A, Murphy D, Vathsala A. Outcomes of Care by Geriatricians and Non-geriatricians in an Academic Hospital. Front Med (Lausanne). 2022 Jun 6;9:908100. doi: 10.3389/fmed.2022.908100. PMID: 35733862; PMCID: PMC9208654.
2. Merchant RA, Aprahamian I, Woo J, Vellas B, Morley JE. Editorial: Resilience And Successful Aging. J Nutr Health Aging. 2022;26(7):652-656. doi: 10.1007/s12603-022-1818-4. PMID: 35842754; PMCID: PMC9209635.
3. Chen MZ, Chan YH, Wong MWK, Merchant RA. Comparison of Rapid Cognitive Screen against Montreal Cognitive Assessment in screening for cognitive impairment in the old and old-old. Psychogeriatrics. 2022 Jul;22(4):460-468. doi: 10.1111/psyg.12841. Epub 2022 May 16. PMID: 35577347; PMCID: PMC9325369.
4. Ho V, Merchant RA. The Acceptability of Digital Technology and Tele-Exercise in the Age of COVID-19: Cross-sectional Study. JMIR Aging. 2022 Apr 13;5(2):e33165. doi: 10.2196/33165. PMID: 35294921; PMCID: PMC9009381.
5. Merchant RA, Seetharaman S, Au L, Wong MWK, Wong BLL, Tan LF, Chen MZ, Ng SE, Soong JTY, Hui RJY, Kwek SC, Morley JE. Relationship of Fat Mass Index and Fat Free Mass Index With Body Mass Index and Association With Function, Cognition and Sarcopenia in Pre-Frail Older Adults. Front Endocrinol (Lausanne). 2021 Dec 24;12:765415. doi: 10.3389/fendo.2021.765415. PMID: 35002957; PMCID: PMC8741276.
6. Ng ZX, Zheng H, Chen MZ, Soon YY, Ho F. Comprehensive Geriatric Assessment guided treatment versus usual care for older adults aged 60 years and above with cancer. Cohrane Database of Systematic Reviews. 2021(10). doi: 10.1002/14651858.cd014875
7. Izquierdo M, Merchant RA, Morley JE, et al. International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines. J Nutr Health Aging. 2021;25(7):824-853. doi: 10.1007/s12603-021-1665-8. PMID: 34409961.
8. Merchant RA, Chan YH, Hui RJY, Tsoi CT, Kwek SC, Tan WM, Lim JY, Sandrasageran S, Wong BLL, Chen MZ, Ng SE, Morley JE. Motoric cognitive risk syndrome, physio-cognitive decline syndrome, cognitive frailty and reversibility with dual-task exercise. Exp Gerontol. 2021 Jul 15;150:111362. doi: 10.1016/j.exger.2021.111362. Epub 2021 Apr 19. PMID: 33887381.
9. Merchant RA, Tsoi CT, Tan WM, Lau W, Sandrasageran S, Arai H. Community-Based Peer-Led Intervention for Healthy Ageing and Evaluation of the 'HAPPY' Program. J Nutr Health Aging. 2021;25(4):520-527. doi: 10.1007/s12603-021-1606-6. PMID: 33786571; PMCID: PMC7883995.
10. Ho V, Chen C, Ho S, Hooi B, Chin LS, Merchant RA. Healthcare utilisation in the last year of life in internal medicine, young-old versus old-old. BMC Geriatr. 2020 Nov 23;20(1):495. doi: 10.1186/s12877-020-01894-0. PMID: 33228566; PMCID: PMC7685638.
11. Merchant RA, Chen MZ, Wong BLL, Ng SE, Shirooka H, Lim JY, Sandrasageran S, Morley JE. Relationship Between Fear of Falling, Fear-Related Activity Restriction, Frailty, and Sarcopenia. J Am Geriatr Soc. 2020 Nov;68(11):2602-2608. doi: 10.1111/jgs.16719. Epub 2020 Aug 17. PMID: 32804411.
12. Ho VWT, Chen C, Merchant RA. Cumulative Effect of Visual Impairment, Multimorbidity, and Frailty on Intrinsic Capacity in Community-Dwelling Older Adults. J Aging Health. 2020 Aug-Sep;32(7-8):670-676. doi: 10.1177/0898264319847818. Epub 2019 May 8. PMID: 31068051.
13. Merchant RA, Hui RJY, Kwek SC, Sundram M, Tay A, Jayasundram J, Chen MZ, Ng SE, Tan LF, Morley JE. Rapid Geriatric Assessment Using Mobile App in Primary Care: Prevalence of Geriatric Syndromes and Review of Its Feasibility. Front Med (Lausanne). 2020 Jul 8;7:261. doi: 10.3389/fmed.2020.00261. PMID: 32733901; PMCID: PMC7360669.
14. Merchant RA, Chen MZ, Ng SE, Sandrasageran S, Wong BLL. Letter to the Editor: The Role of a Geriatrician Has Become Even More Important in an Academic Institution during COVID-19. J Nutr Health Aging. 2020;24(6):681-682. doi: 10.1007/s12603-020-1387-3. PMID: 32510123; PMCID: PMC7220849.
15. Merchant RA, Chen MZ, Tan LWL, Lim MY, Ho HK, van Dam RM. Singapore Healthy Older People Everyday (HOPE) Study: Prevalence of Frailty and Associated Factors in Older Adults. J Am Med Dir Assoc. 2017 Aug 1;18(8):734.e9-734.e14. doi: 10.1016/j.jamda.2017.04.020. Epub 2017 Jun 13. PMID: 28623152.
16. Wong BLL, Chan YH, O'Neill GK, Murphy D, Merchant RA. Frailty, length of stay and cost in hip fracture patients. Osteoporos Int. 2023 Jan;34(1):59-68. Doi: 10.1007/s00198-022-06553-1. Epub 2022 Oct 5.